Molecular target
5-HT2A Receptor
Serotonin receptor with roles in mood, perception, and HPA-axis regulation.
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
No PHI / HIPAA notice: Do not share Protected Health Information (PHI) of any patient on this site — including names, dates of birth, addresses, MRNs, or any identifying information. Use abstract case framing only. Sharing PHI with non-covered entities risks HIPAA violation regardless of platform capability.
Pharmaceutical agents
Drugs that act on 5-HT2A Receptor
These medications have 5-HT2A Receptor among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on 5-HT2A Receptor
Each plant below contains a named compound documented to act on 5-HT2A Receptor. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- MescalinePhenethylamine alkaloid
Foundational classical psychedelic — first phenethylamine isolated (Heffter 1897) and the prototype for the broader phenethylamine class (subsequently 2C-B and others). 5-HT2A agonism is the mechanism shared with psilocybin and LSD. Long duration (~10-12 hours). Effects characteristically include nausea/emesis (often considered ceremonially significant in NAC and other traditional contexts).
- Other phenethylamines (β-phenethylamine, hordenine)Phenethylamine alkaloid
Auxiliary alkaloids contributing to the broader phenethylamine profile of peyote.
- N,N-Dimethyltryptamine (DMT)Tryptamine alkaloid
Primary visionary psychoactive — 5-HT2A agonism is the mechanism shared with psilocybin and LSD. From Psychotria viridis (chacruna) leaf in classical ayahuasca, or Diplopterys cabrerana (chaliponga) in some preparations. Schedule I in the US.
- NuciferineAporphine alkaloid
D2 receptor antagonist with 5-HT1A/5-HT2A modulation — receptor-binding profile resembles atypical antipsychotics in vitro.