Target Index
Walk the graph by mechanism.
110 molecular targets — receptors, enzymes, and pathways the dataset reasons over. Each target is a hub: every drug that acts on it and every plant whose compounds reach it, with the sourced reason on each edge. A shared target is a mechanistic relationship, never a substitution.
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
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NF-κB Pathway
32 drugs · 62 plants
Cyclooxygenase-2
24 drugs · 37 plants
GABA-ergic System
26 drugs · 26 plants
Prostaglandin E2
28 drugs · 13 plants
α1-Adrenergic Receptor
35 drugs · 4 plants
H1 Histamine Receptor
35 drugs · 1 plant
D2 Dopamine Receptor
31 drugs · 3 plants
Serotonin Transporter
28 drugs · 5 plants
Norepinephrine Transporter
30 drugs · 2 plants
AMP-Activated Protein Kinase
3 drugs · 27 plants
M1 Muscarinic Receptor
23 drugs · 4 plants
5-HT2A Receptor
22 drugs · 3 plants
Cyclooxygenase-1
16 drugs · 9 plants
Voltage-Gated Sodium Channel
22 drugs · 3 plants
Xanthine Oxidase
2 drugs · 22 plants
μ-Opioid Receptor
20 drugs · 2 plants
Estrogen Receptor (ERα / ERβ)
8 drugs · 13 plants
Mast Cell Stabilization Pathway
15 drugs · 6 plants
β1-Adrenergic Receptor
20 drugs · 1 plant
Glucocorticoid Receptor
17 drugs · 3 plants
Nitric Oxide / cGMP Pathway
5 drugs · 15 plants
L-Type Voltage-Gated Calcium Channel
14 drugs · 5 plants
Tumor Necrosis Factor-α
7 drugs · 12 plants
M2 Muscarinic Receptor
14 drugs · 4 plants
M3 Muscarinic Receptor
15 drugs · 3 plants
β2-Adrenergic Receptor
16 drugs · 2 plants
ACE / RAAS Pathway
10 drugs · 6 plants
Dopamine Transporter
14 drugs · 2 plants
5-HT1A Receptor
10 drugs · 5 plants
Acetylcholinesterase
7 drugs · 8 plants
Protein Tyrosine Kinase Signaling (broad)
14 drugs · 1 plant
α2-Adrenergic Receptor
13 drugs · 2 plants
NMDA Glutamate Receptor
11 drugs · 3 plants
PPAR-γ
6 drugs · 8 plants
TRPV1 Receptor
1 drug · 12 plants
D1 Dopamine Receptor
10 drugs · 2 plants
HIV Reverse Transcriptase
12 drugs · 0 plants
HMG-CoA Reductase
7 drugs · 5 plants
Monoamine Oxidase A
5 drugs · 7 plants
Monoamine Oxidase B
6 drugs · 6 plants
Adenosine Receptor System
5 drugs · 6 plants
BDNF / Neuroplasticity Pathway
7 drugs · 4 plants
Nicotinic Acetylcholine Receptor (α4β2)
4 drugs · 7 plants
Thromboxane A2 Pathway
3 drugs · 8 plants
5-Lipoxygenase
3 drugs · 7 plants
Lanosterol 14α-Demethylase
7 drugs · 3 plants
Insulin Receptor
5 drugs · 4 plants
Plasmodium Heme Polymerization
5 drugs · 4 plants
Angiotensin II Type 1 Receptor
8 drugs · 0 plants
CGRP / CGRP Receptor Pathway
8 drugs · 0 plants
TRPM8 (Cold/Menthol Receptor)
1 drug · 7 plants
5-HT1B Receptor
7 drugs · 0 plants
5-HT1D Receptor
7 drugs · 0 plants
5α-Reductase
3 drugs · 4 plants
Coagulation Factor Xa
7 drugs · 0 plants
EGFR (Epidermal Growth Factor Receptor)
5 drugs · 2 plants
H⁺/K⁺ ATPase (Proton Pump)
7 drugs · 0 plants
HPA-Axis Modulation
2 drugs · 5 plants
Viral DNA Polymerase
6 drugs · 1 plant
CB2 Cannabinoid Receptor
2 drugs · 4 plants
Dipeptidyl Peptidase-4
4 drugs · 2 plants
Pancreatic ATP-Sensitive K⁺ Channel
5 drugs · 1 plant
Phosphodiesterase-4
5 drugs · 1 plant
Phosphodiesterase-5
6 drugs · 0 plants
Thrombin (Factor IIa)
6 drugs · 0 plants
VEGF / VEGFR Angiogenesis Signaling
4 drugs · 2 plants
5-HT3 Receptor
5 drugs · 0 plants
Calcineurin (PP2B)
4 drugs · 1 plant
Dectin-1 (β-Glucan Receptor / CLEC7A)
0 drugs · 5 plants
GLP-1 Receptor
5 drugs · 0 plants
HCV NS5A Protein / NS5B Polymerase
5 drugs · 0 plants
HIV Integrase
5 drugs · 0 plants
κ-Opioid Receptor
3 drugs · 2 plants
5-HT2C Receptor
4 drugs · 0 plants
Aromatase (CYP19A1)
3 drugs · 1 plant
Cyclin-Dependent Kinases / Cell Cycle
3 drugs · 1 plant
Dihydrofolate Reductase
4 drugs · 0 plants
Distal Convoluted Tubule Na-Cl Cotransporter
4 drugs · 0 plants
Mineralocorticoid Receptor
3 drugs · 1 plant
Na-K-Cl Cotransporter (Loop of Henle)
4 drugs · 0 plants
P2Y12 ADP Receptor
4 drugs · 0 plants
Platelet-Activating Factor Pathway
1 drug · 3 plants
Vitamin K Epoxide Reductase
1 drug · 3 plants
5-HT1F Receptor
3 drugs · 0 plants
Aromatic L-Amino Acid Decarboxylase (DOPA Decarboxylase)
1 drug · 2 plants
BCR-ABL Tyrosine Kinase
3 drugs · 0 plants
Cardiac Na+/K+ ATPase
1 drug · 2 plants
CB1 Cannabinoid Receptor
2 drugs · 1 plant
Cysteinyl Leukotriene Receptor 1
3 drugs · 0 plants
IL-6 Receptor
3 drugs · 0 plants
Melatonin Receptor (MT1 / MT2)
2 drugs · 1 plant
Microtubule (β-Tubulin)
2 drugs · 1 plant
Nerve Growth Factor Pathway
1 drug · 2 plants
Orexin Receptor (OX1 / OX2)
3 drugs · 0 plants
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9)
3 drugs · 0 plants
PI3K–Akt–mTOR Growth Pathway
1 drug · 2 plants
Sodium-Glucose Cotransporter 2
3 drugs · 0 plants
Thyroid Hormone Pathway
2 drugs · 1 plant
β3-Adrenergic Receptor
2 drugs · 1 plant
κ-Opioid Receptor (selective focus)
2 drugs · 1 plant
Catechol-O-Methyltransferase
2 drugs · 0 plants
GSK-3 / Inositol Phosphate Pathway
1 drug · 1 plant
Heme-Iron Radical / Endoperoxide Alkylation
1 drug · 1 plant
Neprilysin
2 drugs · 0 plants
RANKL (Receptor Activator of NF-κB Ligand)
1 drug · 1 plant
Synaptic Vesicle Glycoprotein 2A
2 drugs · 0 plants
Thyroid Peroxidase
2 drugs · 0 plants
Type I Iodothyronine 5'-Deiodinase
1 drug · 1 plant
Cardiac HCN Channel (If current)
1 drug · 0 plants
GIP Receptor
1 drug · 0 plants