Molecular target
Aromatase (CYP19A1)
Enzyme converting androgens (testosterone, androstenedione) to estrogens (estradiol, estrone). Inhibition (anastrozole, letrozole, exemestane) is the cornerstone of postmenopausal hormone-receptor-positive breast cancer therapy. Several plant compounds have weak aromatase-inhibiting activity (chrysin, white button mushroom polysaccharides).
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
No PHI / HIPAA notice: Do not share Protected Health Information (PHI) of any patient on this site — including names, dates of birth, addresses, MRNs, or any identifying information. Use abstract case framing only. Sharing PHI with non-covered entities risks HIPAA violation regardless of platform capability.
Pharmaceutical agents
Drugs that act on Aromatase (CYP19A1)
These medications have Aromatase (CYP19A1) among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Aromatase (CYP19A1)
Each plant below contains a named compound documented to act on Aromatase (CYP19A1). The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- ApigeninFlavone
Apigenin is the principal flavone studied in parsley. In vitro and animal research has investigated inhibition of COX-2 and NF-κB inflammatory signalling, suppression of TNF-α, and aromatase (CYP19A1) inhibition. Human absorption following parsley intake was confirmed in a randomised crossover trial (Nielsen et al., 1999), though downstream target engagement was measured via oxidative-stress biomarkers rather than direct receptor assays.