Molecular target
CB2 Cannabinoid Receptor
Also: CNR2 · id CB2
Primarily peripheral and immune-cell cannabinoid receptor; mediates anti-inflammatory and immunomodulatory effects without psychoactivity.
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
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Pharmaceutical agents
Drugs that act on CB2 Cannabinoid Receptor
These medications have CB2 Cannabinoid Receptor among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on CB2 Cannabinoid Receptor
Each plant below contains a named compound documented to act on CB2 Cannabinoid Receptor. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- Δ9-Tetrahydrocannabinol (THC)Psychoactive cannabinoid
Partial agonist at CB1 (psychoactivity, analgesia, appetite, memory effects) and CB2 (anti-inflammatory, immune).
- Cannabigerol (CBG)Cannabinoid (parent)
Precursor cannabinoid with weak CB1/CB2 partial agonism and α2-adrenergic activity. Lower psychoactivity than THC.
- Cannabinol (CBN)Cannabinoid (degradation)
Degradation product of THC; weak CB2 binding contributes to its sedative reputation.
- β-CaryophylleneTerpene
Selective CB2 agonist also found in many other plants (black pepper, clove); contributes to anti-inflammatory effects without psychoactivity.
- β-caryophylleneSesquiterpene
β-caryophyllene is a selective CB2 receptor agonist; preclinical studies report associated modulation of NF-κB signalling and reduction of COX-2-mediated prostaglandin synthesis. Cited mechanistic studies investigate this as a basis for the oleoresin's reported anti-inflammatory activity.
- β-CaryophylleneSesquiterpene
Preclinical evidence suggests selective CB2 agonism with downstream attenuation of NF-κB and TNF-α; proposed to contribute to anti-inflammatory activity.
- AlkamidesFatty acid amide
Lipophilic alkamides bind CB2 receptors — overlap with cannabis's anti-inflammatory pathway. Believed to be the primary immunomodulatory compounds.