Molecular target
Catechol-O-Methyltransferase
Enzyme degrading catecholamines (dopamine, norepinephrine, epinephrine) and L-DOPA. Inhibition (entacapone, tolcapone) extends levodopa's central availability — used in Parkinson's. COMT genetic polymorphisms (Val158Met) affect dopamine clearance and influence response to multiple psychotropics.
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Pharmaceutical agents
Drugs that act on Catechol-O-Methyltransferase
These medications have Catechol-O-Methyltransferase among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.