Molecular target
Lanosterol 14α-Demethylase
Also: Fungal CYP51 · id CYP51A
Fungal cytochrome enzyme essential for ergosterol biosynthesis (the fungal cell-membrane sterol equivalent of mammalian cholesterol). Inhibition by azole antifungals (fluconazole, itraconazole, voriconazole) disrupts membrane integrity. Several plant compounds (allicin in garlic, terpinen-4-ol in tea tree) have antifungal mechanisms via different pathways.
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Pharmaceutical agents
Drugs that act on Lanosterol 14α-Demethylase
These medications have Lanosterol 14α-Demethylase among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Lanosterol 14α-Demethylase
Each plant below contains a named compound documented to act on Lanosterol 14α-Demethylase. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- CarvacrolPhenolic monoterpenoid
Primary antimicrobial constituent (50-80% of oregano essential oil). Disrupts microbial membranes and inhibits ergosterol biosynthesis (mechanistically similar to azole antifungals).
- ThymolPhenolic monoterpenoid
Co-dominant phenolic monoterpenoid with similar antimicrobial profile; same compound abundant in thyme.
- CinnamaldehydePhenylpropanoid aldehyde
Studies report cinnamaldehyde may activate TRPV1, modulate NF-κB signalling, suppress TNF-α production, and inhibit fungal lanosterol 14α-demethylase (CYP51A), investigated as a basis for antifungal and anti-inflammatory activities.
- Citral / Geraniol (terpenoids)Monoterpenoid
In vitro antifungal activity attributed in part to membrane disruption and possible CYP51A (lanosterol 14α-demethylase) interference; mechanistic data are preclinical.