Molecular target
Dectin-1 (β-Glucan Receptor / CLEC7A)
Also: CLEC7A, β-glucan receptor · id DECTIN1
Innate-immune pattern-recognition receptor on macrophages, dendritic cells, and neutrophils that binds fungal β-(1,3)/(1,6)-D-glucans and initiates innate immune signaling. The principal receptor through which medicinal-mushroom β-glucans (lentinan, PSK/krestin, D-fraction) have been studied for immunomodulatory activity. No approved small-molecule drug targets this receptor directly.
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Botanical connections
Plants whose compounds act on Dectin-1 (β-Glucan Receptor / CLEC7A)
Each plant below contains a named compound documented to act on Dectin-1 (β-Glucan Receptor / CLEC7A). The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- Lentinan (β-1,3/β-1,6-glucan)β-glucan polysaccharide
Lentinan, shiitake’s principal β-glucan, has been studied as an agonist of the Dectin-1 (CLEC7A) innate-immune receptor; this β-glucan–receptor binding is the documented basis of its investigated immunomodulatory activity.
- PSK (polysaccharide-K / krestin)β-glucan-protein complex
PSK (krestin), turkey tail’s characterized polysaccharide-K, has been studied as an agonist of the Dectin-1 (CLEC7A) β-glucan receptor; this binding is the documented basis of the immunomodulatory activity investigated for Trametes versicolor.
- β-Glucans (D-fraction / MD-fraction)β-glucan polysaccharide
Maitake D-/MD-fraction β-glucans have been studied as Dectin-1 (CLEC7A) agonists; this receptor binding is the documented basis of the immunomodulatory activity investigated for Grifola frondosa.
- Ganoderma β-glucans (β-1,3/1,6-D-glucans)β-glucan polysaccharide
Reishi β-glucans have been studied as agonists of the Dectin-1 (CLEC7A) innate-immune receptor; this β-glucan–receptor binding is the documented basis of the immunomodulatory activity investigated for Ganoderma.
- β-Glucans (polysaccharides)β-glucan polysaccharide
Chaga β-glucan polysaccharides have been studied as ligands of the Dectin-1 (CLEC7A) innate-immune receptor, the documented basis of the immunomodulatory activity investigated for Inonotus obliquus.