Molecular target
Type I Iodothyronine 5'-Deiodinase
Also: DIO1, T4-to-T3 conversion · id DEIODINASE
Peripheral enzyme that converts thyroxine (T4) to the active triiodothyronine (T3). Inhibited by propylthiouracil — its T3-lowering secondary mechanism that distinguishes it from methimazole — and reported for Lycopus (bugleweed) phenolic acids in the setting of mild hyperthyroidism.
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
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Pharmaceutical agents
Drugs that act on Type I Iodothyronine 5'-Deiodinase
These medications have Type I Iodothyronine 5'-Deiodinase among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Type I Iodothyronine 5'-Deiodinase
Each plant below contains a named compound documented to act on Type I Iodothyronine 5'-Deiodinase. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- Lithospermic acid (+ caffeic acid derivatives)Phenolic acid
Lycopus phenolic acids have been reported to inhibit peripheral type-I 5'-deiodinase (T4→T3 conversion) and to interfere with TSH binding — the documented basis of traditional use in mild hyperthyroidism. The deiodinase action is the one shared with propylthiouracil.