Molecular target
Dihydrofolate Reductase
Enzyme reducing dihydrofolate to tetrahydrofolate, essential for nucleotide synthesis. Inhibition by methotrexate (high-affinity, mammalian DHFR) drives anti-proliferative effect; trimethoprim selectively inhibits bacterial DHFR.
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Pharmaceutical agents
Drugs that act on Dihydrofolate Reductase
These medications have Dihydrofolate Reductase among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.