Molecular target
Dipeptidyl Peptidase-4
Enzyme that degrades incretins (GLP-1, GIP). Inhibition (sitagliptin, linagliptin) prolongs endogenous incretin action. Some plants (fenugreek, others) have mild DPP-4 inhibitory activity.
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
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Pharmaceutical agents
Drugs that act on Dipeptidyl Peptidase-4
These medications have Dipeptidyl Peptidase-4 among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Dipeptidyl Peptidase-4
Each plant below contains a named compound documented to act on Dipeptidyl Peptidase-4. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- DPP-IV inhibitory peptidesBioactive peptides
In vitro research reports that peptides released from amaranth seed proteins after simulated gastrointestinal digestion may inhibit dipeptidyl peptidase IV (DPP-IV), an enzyme involved in incretin degradation, with an IC₅₀ of ~1.1 mg/mL (Velarde-Salcedo et al., 2013).
- TrigonellineAlkaloid
Mild DPP-4 inhibitory activity; antioxidant.