Molecular target
Heme-Iron Radical / Endoperoxide Alkylation
Also: artemisinin activation · id HEME_IRON_RADICAL
Heme-iron–mediated free-radical mechanism: parasite ferrous iron cleaves the artemisinin endoperoxide bridge, generating carbon-centered radicals that alkylate heme and parasite proteins. The artemisinin antimalarial mechanism — distinct from heme-polymerization (hemozoin) inhibition by quinoline antimalarials such as chloroquine and quinine.
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Pharmaceutical agents
Drugs that act on Heme-Iron Radical / Endoperoxide Alkylation
These medications have Heme-Iron Radical / Endoperoxide Alkylation among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Heme-Iron Radical / Endoperoxide Alkylation
Each plant below contains a named compound documented to act on Heme-Iron Radical / Endoperoxide Alkylation. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- ArtemisininSesquiterpene endoperoxide lactone
Artemisinin’s endoperoxide bridge is cleaved by heme/ferrous iron to generate carbon-centered radicals that alkylate heme and parasite proteins — the antimalarial mechanism shared with its semi-synthetic derivative artemether.