Molecular target
L-Type Voltage-Gated Calcium Channel
Calcium channel critical for vascular smooth muscle contraction and cardiac conduction. Antagonism by dihydropyridine CCBs (amlodipine, nifedipine) preferentially relaxes vasculature; non-DHP CCBs (verapamil, diltiazem) also slow cardiac conduction.
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Pharmaceutical agents
Drugs that act on L-Type Voltage-Gated Calcium Channel
These medications have L-Type Voltage-Gated Calcium Channel among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on L-Type Voltage-Gated Calcium Channel
Each plant below contains a named compound documented to act on L-Type Voltage-Gated Calcium Channel. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- KhellinFurochromone
Khellin has been reported to inhibit L-type voltage-gated calcium channels, producing smooth-muscle relaxation in bronchial and vascular tissues; it is also reported to stabilise mast cells, reducing mediator release. These mechanisms are considered the pharmacological basis for khellin's structural inspiration for the development of cromolyn sodium and nifedipine, per review literature.
- VisnaginFurochromone
Visnagin shares calcium-channel-modulating properties with khellin; in vitro studies report that visnagin, alongside khellin, may reduce oxalate-induced renal epithelial cell damage, with a proposed mechanism involving modulation of calcium-dependent cellular injury pathways.
- Berbaminebisbenzylisoquinoline alkaloid
Calcium-channel modulating activity contributes to mild antiarrhythmic and vasodilatory effects observed in preclinical models.
- Panax notoginseng saponins (PNS) — notoginsenoside R1, ginsenoside Rb1, ginsenoside Rg1Triterpenoid saponins
Studies report multi-target activity: inhibition of NF-κB–mediated neuroinflammation, modulation of thromboxane A2 and arachidonic acid pathways to attenuate platelet aggregation, nitric oxide/cGMP pathway modulation, NMDA receptor involvement in neuroprotection, and L-type calcium channel effects relevant to cardiovascular research contexts.
- 3-n-Butylphthalide (NBP)Phthalide
Proposed mechanisms include vasodilatory activity via calcium channel modulation, nitric oxide/cGMP pathway enhancement, and ACE inhibition; anxiolytic and antidepressant-related activity investigated in preclinical models via GABAergic and serotonergic pathways. Clinical data from Shayani Rad et al. (2022, 2023) investigated these effects in hypertensive patients.
- Tanshinone IIAditerpenoid quinone
Calcium-channel modulating activity contributes to vasodilation, anti-arrhythmic, and the anti-fibrotic effects observed in cardiac trials.