Educational only. Not medical advice. Invite-only research preview.No PHI. Do not share patient names or identifying information (HIPAA).
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All targets

Molecular target

Norepinephrine Transporter

Also: SLC6A2 · id NET

Reuptake transporter for norepinephrine. Targeted by SNRIs and certain TCAs.

30 drugs act here2 plants reach it via their compounds

Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.

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Pharmaceutical agents

Drugs that act on Norepinephrine Transporter

These medications have Norepinephrine Transporter among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.

AmitriptylineAmoxapineAtomoxetineBenzphetamineBupropionClomipramineDesipramineDesvenlafaxineDexmethylphenidateDextroamphetamineDiethylpropionDoxepinDuloxetineImipramineLevomilnacipranLisdexamfetamineMethamphetamineMethylphenidateMilnacipranMixed Amphetamine SaltsNefazodoneNortriptylineParoxetinePhendimetrazinePhentermineProtriptylineTapentadolTramadolVenlafaxineZiprasidone

Botanical connections

Plants whose compounds act on Norepinephrine Transporter

Each plant below contains a named compound documented to act on Norepinephrine Transporter. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.

Khat
A
  • CathinonePhenylalkylamine alkaloid

    Primary psychoactive constituent; structurally and pharmacologically analogous to amphetamine. Research indicates it may promote monoamine release and inhibit reuptake at DAT, NET, and SERT, and may inhibit MAO-A and MAO-B. Degrades rapidly on storage, which is why leaves are chewed fresh.

  • Cathine (norpseudoephedrine)Phenylalkylamine alkaloid

    Less potent sympathomimetic than cathinone; may contribute to cardiovascular and appetite-suppressing effects reported in human chewing studies.

St. John's Wort
A
  • HyperforinPhloroglucinol

    Primary antidepressant constituent; inhibits SERT, NET, and DAT through a non-classical mechanism (TRPC6-mediated). Major source of CYP3A4 induction → drug-interaction profile.

A shared molecular target shows how a botanical and a drug relate mechanistically. It is not evidence that one can replace the other. Educational summary only — discuss any medication decision with your clinician.