Molecular target
Na-K-Cl Cotransporter (Loop of Henle)
Renal thick ascending limb cotransporter. Inhibition by loop diuretics (furosemide, bumetanide, torsemide) blocks sodium reabsorption, producing potent diuresis and electrolyte effects. The most powerful diuretic mechanism class.
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Pharmaceutical agents
Drugs that act on Na-K-Cl Cotransporter (Loop of Henle)
These medications have Na-K-Cl Cotransporter (Loop of Henle) among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.