Molecular target
Thyroid Hormone Pathway
Levothyroxine (T4) and liothyronine (T3) activate nuclear thyroid receptors regulating metabolism, growth, and development. Plants relevant here either supplement iodine (bladderwrack), modulate TPO (bugleweed), or alter T4 metabolism (ashwagandha — increases T4).
Educational use only. This page summarizes published research and traditional-use records for educational purposes. It does not diagnose, treat, cure, or prevent any disease. Do not start, stop, or change medications based on this information. Discuss any decisions about therapies — pharmaceutical or botanical — with a qualified clinician who knows your medical history.
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Pharmaceutical agents
Drugs that act on Thyroid Hormone Pathway
These medications have Thyroid Hormone Pathway among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Thyroid Hormone Pathway
Each plant below contains a named compound documented to act on Thyroid Hormone Pathway. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- Guggulsterones (Z- and E-isomers)Steroidal ketones
Studies report guggulsterones modulate bile acid receptor (FXR) antagonism, suppress NF-κB signalling, inhibit 5-lipoxygenase, and have been reported to influence thyroid hormone receptor activity and HMG-CoA reductase pathway — proposed contributors to observed lipid-modulating effects in clinical studies.