Molecular target
Vitamin K Epoxide Reductase
Also: VKORC1 · id VKORC1
Recycles oxidized vitamin K to its active form, enabling γ-carboxylation of clotting factors II, VII, IX, X, protein C, and protein S. Inhibition by warfarin produces the anticoagulant effect. Plants high in vitamin K (leafy greens) and several botanical inhibitors (St. John's Wort via CYP induction, garlic, ginkgo, ginger via TXA2/antiplatelet pathways) interact here.
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Pharmaceutical agents
Drugs that act on Vitamin K Epoxide Reductase
These medications have Vitamin K Epoxide Reductase among their molecular targets. Sharing a target is a mechanistic relationship — it does not make any plant below an alternative to, or substitute for, these drugs.
Botanical connections
Plants whose compounds act on Vitamin K Epoxide Reductase
Each plant below contains a named compound documented to act on Vitamin K Epoxide Reductase. The compound and the reason for the connection are shown on every edge — a shared mechanism, not a therapeutic equivalence.
- Reserpine (A. constricta)
Placeholder - replaced below
- Coumarins (Angelica sinensis coumarin constituents)
Dong Quai's coumarin content is the documented basis for its anticoagulant interaction/bleeding-risk warning (notably potentiation of warfarin). Coumarins act on the vitamin K cycle (VKORC1); this compound-specific, well-documented pharmacovigilance link supports rescuing the coagulation mechanism rather than dropping it as generic.
- Vitamin K1 (phylloquinone)Fat-soluble vitamin
Alfalfa leaf is notably rich in vitamin K1, a substrate for VKORC1. High intakes may antagonise vitamin K epoxide reductase inhibitors (e.g., warfarin), reducing anticoagulant effect.